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MitraClip in secondary mitral regurgitation as a bridge to heart transplantation: 1 year outcomes from the International MitraBridge

June 9, 2021 By Sergio

Cardiothoracic Transplant Anesthesia Article of the Month

Godino C, Munafo A, Scotti A, Estevez-Loureiro R, Hernandez AP, et al. MitraClip in secondary mitral regurgitation as a bridge to heart transplantation: 1 year outcomes from the International MitraBridge Registry. J Heart Lung Transplant. 2020 Dec;39(12): 1353-1362.

Abstract:

BACKGROUND: Patients awaiting heart transplantation (HTx) often need bridging therapies to reduce worsening and progression of underlying disease. Limited data are available regarding the use of the MitraClip procedure in secondary mitral regurgitation for this clinical condition.

METHODS: We evaluated an international, multicenter (17 centers) registry including 119 patients (median age: 58 years) with moderate-to-severe or severe secondary mitral regurgitation and advanced heart failure (HF) (median left ventricular ejection fraction: 26%) treated with MitraClip as a bridge strategy according to 1 of the following criteria: (1) patients active on HTx list (in list group) (n = 31); (2) patients suitable for HTx but awaiting clinical decision (bridge to decision group) (n = 54); or (3) patients not yet suitable for HTx because of potentially reversible relative contraindications (bridge to candidacy group) (n = 34).

RESULTS: Procedural success was achieved in 87.5% of cases, and 30-day survival was 100%. At 1 year, Kaplan−Meier estimates of freedom from the composite primary end-point (death, urgent HTx or left ventricular assist device implantation, first rehospitalization for HF) was 64%. At the time of last available follow-up (median: 532 days), 15% of patients underwent elective transplant, 15.5% remained or could be included in the HTx waiting list, and 23.5% had no more indication to HTx because of clinical improvement.

CONCLUSIONS: MitraClip procedure as a bridge strategy to HTx in patients with advanced HF with significant mitral regurgitation was safe, and two thirds of patients remained free from adverse events at 1 year. These findings should be considered exploratory and hypothesis-generating to guide further study for percutaneous intervention in high-risk patients with advanced HF. “

Expert Summary by Barbara Wilkey, MD

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References:

  1. Feldman T, Foster E, Glower DD, Kar S, Rinaldi MJ, Fail PS, Smalling RW, Siegel R, Rose GA, Engeron E, Loghin C, Trento A, et al. for the EVEREST II Investigators. Percutaneous Repair or Surgery for Mitral Regurgitation. N Engl J Med 2011;364:1395-1406.
  2. Stone GW, Lindenfeld J, Abraham WT, Kar S, Lim S, Mishell JM, Whisenant B, Grayburn PA, Rinaldi M, Kapadia SR, Rajagopal V, Sarembock IJ et al. for the COAPT Investigators. Transcatheter Mitral-Valve Repair in Patients with Heart Failure. N Engl J Med 2018; 379: 2307-2318.

Filed Under: Article of the Month, Education

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